How much is a ticket from Santo Domingo to Mayaguez?

Depending on when you travel and how far in advance you book, fares between Santo Domingo and Mayaguez can differ a lot.

Choose a date to explore the best fares now.

If you’re flexible with timing, consider overnight flights — they often cost less and are less crowded. Exploring multiple date and time combinations can help you find the cheapest solution.

Which airports serve Santo Domingo and Mayaguez?

When planning a trip of about 267 km, it's a good idea to check flights from surrounding airports too.

• Airports in Santo Domingo: La Isabela is also an option alongside Santo Domingo - Las Américas.
• Airports in Mayaguez: The only active airport in Mayaguez is Mayaguez - Eugenio Maria de Hostos.

The closest airport isn’t always the cheapest — it’s worth checking the alternatives too. In some cities, smaller airports offer lower fares than the main ones.

Customize your flight from Santo Domingo to Mayaguez

Jetcost allows you to filter by travel dates, duration, layovers, carriers, and booking providers. You’ll find direct and connecting flights, one-way or round-trip, from the best airlines and travel agencies.

Other popular destinations

Thinking about Puerto Rico? You might also consider: Aguadilla, Culebra Airport, Ponce, San Juan, Vieques Airport.

You can sort results by price, duration, or departure time to find the best option for you. When available, results always include both low-cost and traditional airlines.