What’s the cost of a flight from Panama City to Mayaguez?

Prices vary based on date, airline, and availability. Compare several options if you're flying between Panama City and Mayaguez.

Choose a date to explore the best fares now.

If possible, avoid holiday periods: ticket prices tend to rise quickly and availability drops, especially on busy routes. Morning and evening flights are often in high demand too — book early to get a good fare.

Which airports serve Panama City and Mayaguez?

When planning a trip of about 1668 km, it's a good idea to check flights from surrounding airports too.

• Airports in Panama City: Panama City is connected to 2 airports - Pacífico International Airport, Paitilla.
• Airports in Mayaguez: The only active airport in Mayaguez is Mayaguez - Eugenio Maria de Hostos.

The closest airport isn’t always the cheapest — it’s worth checking the alternatives too. In some cities, smaller airports offer lower fares than the main ones.

Customize your flight from Panama City to Mayaguez

Jetcost allows you to filter by travel dates, duration, layovers, carriers, and booking providers. You’ll find direct and connecting flights, one-way or round-trip, from the best airlines and travel agencies.

Other popular destinations

Thinking about Puerto Rico? You might also consider: Aguadilla, Culebra Airport, Mayaguez, Ponce, San Juan.

You can sort results by price, duration, or departure time to find the best option for you. When available, results always include both low-cost and traditional airlines.